I've made many large quilts with a small-throated domestic machine. The key is table space so that the quilt weight is supported, not hanging. Work directionally as turning around that much quilt is difficult. Tight roll the section that must lay inside the throat. Lock the cats out of the sewing room! Wear quilting gloves. Frequently take breaks to pull your shoulders down and stretch your back. Don't try to do it all in one setting! Good luck!