I've quilted up through queen size with my regular ol' Singer. I love that thing. <3
So yes, it can definitely be done! But like luvTooQuilt, you might not like to do it that way. Before you invest a lot of money in any machine see if you can take it for a test drive -- for a while. Like, a 'borrow one from a friend for a couple of weeks and a few quilts' type of thing.
Find out what makes you happy, and then do that!