I quilt on my Bernina 820 machine that has one of the biggest throat openings for DSMs & there are times it gets a little frustrating but it can be done. I love my Bernina & can't imagine quilting on a DSM with a smaller throat opening than mine but I know others have done it & they have my utmost respect because I am sure it would test my patience. I have done 1 queen & several double size & twin size quilts.
If you have the skill
& the patience almost anything is possible. Good luck deciding which DSM you buy.