I quilt on my sewing machine. I mainly do SID, as I really like the way that looks when all is done. I find the quilting process very satisfying. I haven't done anything larger than a twin sized though, so I can't speak to one that size. I think I would just have to be more patient, but I could do it. I have been quilting 3 years and just finished my 50th quilt. (Can you tell I really really like this hobby?)
It really all depends on what you enjoy doing.
Dina