I have quiltied all of mine on a sewing machine, from lap quilt to queens. I have a Viking (base model) and a Pfaff; I will use which ever one is on the table.
I quilt in sections, usually 3 sections, then attach the tops together on the machine. I hand sew the back together, almost like a Quilt-as-you Go method. Yes, I would like a mid-arm or long-arm, but I don't the room for them right now. Just the two.