Are the care instructions you're reading for care of the finished quilt, or for preparing the batting for quilting? How far apart does the package say to quilt it? If it's something like 4 to 8 inches apart, then I would be careful. Having said that, however, I do machine wash and machine dry all my quilts. I mean for them to get used, and it's not practical with most people's lifestyles to not be able to wash them. I have never used the fusible, usually it's W&N, and my washing machine is a front loader.