I don't know that all the seams will necessarily make it harder to hand quilt...I am thinking if you have a nice comfortable thimble and sharp needles that it will make it much easier to get thru the thickness of the seams...also depends on the batting you use..I use warm and natural on a lot of mine, and it is a thinner batting..but the density of it makes it seem thicker than some of the higher loft poly battings...Do you plan to use a hoop? That will make a difference, too with several seams involved. I am sure there will be others along with more experience than I to help you out...good luck with it, and don't forget to post pics!!
Regards,
Kif