I quilt in our 5th wheel all the time! I always have a quilting project that I work on in the camper that is getting done totally by hand. I love doing hand piecing and quilting! I just keep that quilt in the camper and I can work on it inside the camper, outside the camper or while traveling down the road. You would be very surprised how quickly hand piecing and quilting can go.
Sometimes while we are off in the 5th wheel, and I have a special project that I am working on that I am using a machine for, I will bring my mom's old 301a along in the camper to use in the camper. It is really not much larger than a Featherweight and runs so beautifully quiet that I can use it at night after DH goes to bed and it does't bother him at all.
I always have a plastic Tupperware-type container with basic supplies in the camper - various threads, a mat, a couple rulers, a rotary cutter, pins, needles, etc. That just stays in the camper all the time. I don't keep any extra fabric in the camper, just what I need for my current projects that I am working on. If we were going to be gone for a longer period of time, I would plan ahead for a quilt and take a stack of fabric with matching thread, etc. for a longer term quilt. Of course, I would probably forget something that I needed which would necessitate finding a quilt shop along the way. ;-))
I would highly advise trying a hand quilting project to take along! I find working with a needle and thread by hand very soothing!