How often do you have guests in the guest room? If it is only one or two times a year, take it over, you can probably come up with another solutions for over night guests.
I took over our guest bedroom for a sewing room 11 years ago. Never looked back. We have a sofa bed in dh's office and an RV in the driveway where we can put up guests. discovered most guests want to sleep in the RV.