If I were her, I would get these:
http://www.amazon.com/Dritz-Quilting...+guide+refills
and set two on the sewing machine base -- one on each side of the needle -- to guide 2.5" strips through. To sew pairs of strips together, I would move the left guide over so it is 4.5" from the righthand guide.
There is a seam guide that works in a somewhat similar manner. I'm just not sure if it would work better or less well than my idea above:
http://www.amazon.com/Dritz-Seams-Qu...dp/B000AM2MMW/
If at all possible, she should invest in an Accuquilt Studio die cutting machine. This is heavy enough to "stay put" while she operates the crank handle, and would give her a way of cutting pieces. She could even cut shapes out of strip-pieced sets.
Another option is using a rolling cutter like this one:
http://www.amazon.com/Fiskars-12-Inc...dp/B001CE38Z2/
There is another one that might be better, but I cannot remember the name of it now. Fiskars used to have one that was 24" long so you could cut an entire width of fabric in one slice. It was discontinued some time ago, but someone on the QB posted recently that Fiskars is going to bring it back due to demands from quilters.
I found this thread with suggestions:
http://answers.yahoo.com/question/in...2064002AAPbP1U
Edit: I'm thinking that she might want to start with a pattern that does not require matching of seams. I am thinking of a "brick" pattern where rectangles are offset in each row. Also, a jelly roll type quilt might be a good place to start. I saw a fabulous one that a guild member made, and she did not bother to press any seams until after the top was put together. (I'm thinking that ironing would actually be harder for me to do with one hand than sewing would be. If she could put a jelly roll top together, then maybe you could iron it for her. I personally love "the strip stick" for ironing seams.)