I almost do a Quilt As You Go - I generally make Twin or Queen size quilts. I have them in sections or row, usually 3 rows, whatever will be manageable to quilt at one time.
Quilt each section, then I sew two sections together in the front, then sew the next secton to the first part.
Finally I hand sew the backs together. Once that's done, all you need to do is the binding.