I'm currently handquilting a whole cloth quilt. Embroidery in the middle, the rest is plain/nothing.
So I've quilted a cross-hatch in the empty space between the flowers and the border around them. Also, quilted two rows around the border. After that, I've backed it with that pre-printed backing. So I'll just turn it over and follow the lines to finish the quilting.
Be sure to show us your project once you're done.