I am left handed and do most things left handed. I did have to have my roller bars on my LA set up to the left and occasionally will hit the wrong control, since it is set up for righties. I have switched the blade on my Olfa cutters to LH and have ambidextrous scissors.
However, when I went to work at a database company I had to learn how to use more right hand more for both using the keyboard and then the mouse. I did end up with a form of carpal tunnel, but in my right shoulder as well as in my wrist and hand. Thankfully, since I have retired and do less computer work it's not a problem any more.