I have seen it recommended that you do not use the nylon invisible thread on quilts, but to use the polyester invisible thread since the poly is softer and less likely to "poke" - if you are quilting a bed, or baby quilt. The nylon, of course, it fine for a wall hanging, but I have had both and truly prefer the poly one no matter what I'm quilting, since it is just softer and easier to use, in my estimation. I must say, my nylon invisible thread is being ignored in my thread stash.