I have quilted a few this way and find that it is a lot of work hooping and re hooping. When I quilt with my embroidery machine I center the design in a charm square block and not every one is perfect and I only use single run designs for quilting. Emblibrary has plenty of single pass designs to choose from. You MUST have something to support the weight of the quilt while its hooped. It can be done but it will take a lot of time and it will take you constantly watching it, no pushing the button and going to stir dinner, this is when all mistakes and problems will happen, ask me how I know lol.
I have done a twin and a little bit bigger than a twin this way and tho I am happy with them they are far from perfect.
Good Luck and make sure to post pictures of finished product.
T