I think part of it depends on how you plan on quilting it. If you're going to put it on a frame, I don't think it's possible to line it up perfectly. However, if you are going to hand quilt it, or pin-baste it and quilt it on your DSM, I think there is a way to line up the top and backing. It would require patience and dedication, though! Stick a pin through the top at a corner of a block, then down through the batting, then line the pin up with the corresponding corner of the corresponding block on the backing. Do this for every corner of every block, then quilt.
That's how I'd do it - if I had the patience!