As long as you are comfortable sewing with invisible thread there's no reason you can't use it. If you haven't ever worked with it I would suggest doing some testing on scraps first. It can be hard to use at first. Also, if this is a quilt that will be used and washed, not a wall hanging type, I wouldn't use the invisible thread just because it's not as flexible as thread, and may not be as easily cared for. Just my opinion.