Other than using wool batting I have not used wool in a quilt so can't be any help. However I have made the mistake of washing a wool garment and having it shrink up to half the original size, so just from that experience I would think you would need to find washable wool or pre-shrink it before cutting if you are using it in a quilt that will be laundered. If for an art piece or wall hanging, this wouldn't be an issue.