Both of my grandmothers were quilters and seamstresses.
Maternal grandmother made all the kid's clothes, most of the household linens, made quilts like mad, and also could restore & reupholster furniture. Her quilts are VERY warm (lots of them have wool tops & flannel backs), heavy, mostly made of scraps and salvaged clothing, simple piecing (mostly Trip Around the World), sometimes some embroidery, and are all tied. She regarded things mostly in terms of practicality, with aesthetics coming in second. (And her quilts are built like tanks, and are so warm and cozy...they are my favorites.)
Paternal grandmother was a professional seamstress (making slipcovers and heavy draperies), and made dolls and quilts as a hobby. Her quilts are thinner and cooler (some made without batting at all), made with colorful quilting cottons and usually more decorative/complex piecing, and all were machine-quilted. She was more into the art of things, and was also an accomplished oil painter - she used to paint amazingly detailed sailing ships onto clam shells and sell them; and she also sold her dolls and quilts. She also painted on fabric - the dolls she made for my sister & I all had painted faces, and I have a "Popeye" quilt where she painted Popeye onto several blocks of the quilt.
Nobody else in the family quilts now, and unfortunately I didn't pick it up until after they'd both passed away. My Mom's sister does a lot of embroidery; my dad's sisters are both into rug hooking and one of them also got her mom's talent for painting.
I have no idea if any of my great grandmothers were quilters. As far as I know, there are no quilts in the family that could have been made by the prior generation(s). Most of that generation, on both sides of my family, is from Germany and I don't know if quilting was really a thing people did much of in Germany back then.