I use a bucket you get at wally in the paint dept and I line it with a small kitchen trash bag. When im cutting or sewing, all threads and itty bitty pieces to be thrown out, goes into that bucket. When it gets full, which takes quite some time, then I just wrap up the small trash bag and out it goes. My set up is now in a U-shape as I cant stand for long time due to good ole arthur in knees. I have a desk with my pc and printer and shelves over that to hold all my info, quilting books office supplys etc. Then on the the smaller end I have a table with my cutting mat sewing machine and a shelf to hold boxes and small baskets full of things like threads sewing supplys, rulers etc. this table is set up on wooden pieces of board so that my ironing board set in the lowest position will slide partially under that table. the rest of the ironing board sticks out like an arm. Off the end of the ironing board is part of a folding table which I use for my cut fabric layouts. On the other side of the ironing board is an old filing cabinet which I use to store all my fabrics for now. I have an office chair on rollers to slide where I need to be. So any threads or bits of fabrics may drop just in that small area. It is easy then to just pick up anything on the floor and throw it in the bucket to be pitched them. About 2x per week I vacuum that area which is not a large area so its easy to keep it clean. I first take the hose of my vacuum cleaner and suck up any threads on the floor before I actually vacuum the floor using the beater bar on my vac. This saves time and wear n tear on my machine. I envy those who have a nice large organized quilting room and have a place to stash and store everything. Only in my dreams I guess.lol