I have used two layers of warm and natural white. It quilted easily - I did not notice any difference there. It is much heavier and a bit stiffer in terms of drape. The reason I tried it was that I wanted the quilt to be much warmer than a single layer of warm and natural would have been. I would not choose to do it this way again because of the stiffness. I quilted it with a medium to large meander so the quilting is not the reason for the stiffness. Also, there is not any extra puffiness on my quilt. I would go with a extra high loft batting with no tight quilting if you want puffiness and soft drape.