I have quilted two layers of batting: hobbs 80/20 two layers turned out very nice! Hobbs 80/20 with 6 0z polyester bat on top. very nice. quilted heavy leaves it a little stiff perfect for a wall hanging but not for a cuddle quilt!
Did one with one layer of a high loft poly bat was really puffy and very drapey and cuddly.
These were done on a long arm.
I did a quilt using one layer only of Hobbs Tuscany wool and it was beautiful. soft and draped very nice. This was done using my sewing machine.
Hope this helps.