Such a sweet thing to do for your friend. Sounds like she really needs a lot of prayer right now.
I am in a quilt ministry with my church where we make tied prayer quilts. We include a label that says 'This quilt was lovingly made for ......' And it includes the month/year it was made and the verse from Gal 6:2.
When I begin a quilt, from the fabric cutting to the end, I am in prayer for that person. When it is completed all the ministry members get together and pray over the quilt and for that persons specific needs. And we tie the ties that are placed in the quilt.
In my opinion you can make a quilt any way you want - and as long as you are praying for that person - they are covered with prayer while it is being made and then whenever they use it.