It seems like these can be put into categories -
1) mildly vexing, but not damaging to anything - cat hair, for example
2) seriously frustrating - not able to find the fabric, machine part no longer available, etc.
3) almost disastrous - quilt is torn, scorched by the iron, dyes bled, the quilter used the wrong pantograph - the quilt might be unsalvageable - but nothing life-threatening is involved
Truly disastrous - the whole house burns down - one is diagnosed with stage 5 cancer - that sort of thing
Some days - the trivial gets me as riled as the serious problem!