Of course you can. Some fabrics may need stabilizer (silk, t-shirts, some rayons and some poly). If you are using something that can't be washed, you should use it in a wall hanging or something that won't be washed. I have used home dec in quilts. I have used silk and silky poly in quilted pillow covers (left over from DMIL's clothes). I have also used ultra suede (also clothing scraps) in quilts.