I wouldn't trade my Olfa matt and cutter for anything. Although I have a 28 cutter, I rarely use it. I have cut many layers with my 45. I put a new blade in if I'm going to cut many layers. I have cut a Buggy Barn pattern by dividing the block into 2 piles and successfully cut with my 45. I believe Olfa makes their cutters so you can reverse the blade and make it left handed. Look on their website.
Sue