Probably the best reaction was from my daughter and son-in-law.
SIL was undergoing chemo for Hodgkin's Lymphoma, and I secretly worked with his mom to get signatures from all their friends and family (they live 3 1.2 hours away) into friendship blocks.
They both cried, and my daughter just kept saying over and over again, "This is just so awesome!". And I cannot tell you how many quilts she's been given in the past. But this one... well, I don't think there was a dry eye in the house when they received it!!