I would test the applique fuse technique and product you intend to use. I recently used Heat N' Bond Lite on a king size quilt and thought the applique pieces felt very stiff. I wished I had used a temporary adhesive spray instead so it would have been softer. I also used some of it on a baby quilt and just thought those parts were too stiff.
I used Hobbs 80/20 batting and stippled around the appliques. I think it was the batting that made the appliques puff up as much as they did. It was a very nice effect that I probably couldn't have gotten with something like Warm and White/Natural.