I'm not from Columbus, but my daughter lives there and I frequently visit, how long are you going to be there and will you have vehicle to get around ?? If you have a day or two I would defiantly go to these shops.
http://www.redroosterquilts.com
http://www.quilttrends.com
Outside of Columbus but worth the drive
http://www.lunnfabrics.com
http://www.fabricshack.com
I think you'll find most well known hotels near the airport to be safe,and as always be aware of your surroundings etc.... check out Hotels.com if you want a better idea of the hotel and reviews, I have found they are spot on 99.99% of the time...have fun!!