SITD is easier with a big quilt and a domestic machine. I have done QAYG and it's a lot of fun, but you definitely have to plan on making it that way from the beginning. It doesn't work easily on all quilts.
I find that I can do some FMQ (I am horrible at it, so use stencils LOL) on a quilt that is 40x40. Anything bigger than that and I get frustrated and give up, or do SITD.
Also, with a large quilt you want to make sure you have lots of table space to hold the weight of the quilt - all the way around, otherwise you will get frustrated with the pulling and dragging of the quilt as you are trying to sew.
Good luck