I do it all the time with bamboo batting. I made one without batting, just top and fleece, but my kids prefer to have all three layers. Too hot for me. As far as how the quilt holds up, seems to be just fine. I spray baste and quilt on my DSM with a walking foot. I've bought all of my fleece at JoAnns when it is on sale. I hesitantly pieced some fleece for a bigger quilt and it did fine, too. I didn't have any trouble with "slippage" using the spray baste. I bind the quilts the normal way, generally using left over cotton from the quilt top for the binding.