I big stitch just about everything. I have tried all the crochet thread sizes and find that #10 is very hard to pull through the fabric, but size #20 and #30 are great. They generally only come in white or ecru, so I bought a bunch on EBay and will play around someday with dying them. I would think it should hold up fairly well, women made table cloths and bedspreads from cotton crochet thread and they held up well, so quilting with them shouldn't be a problem. I also use Perle cotton size 8 and 12 (size 5 is a bear to pull through the layers), and 12 wt thread. Have used 3 strands of embroidery thread on small items when it's the only thread I have in the right color, but it probably wouldn't stand up to the wear and tear a big quilt gets with use.