I think the general rule of thumb for tying quilts is a hand-width apart in all directions. And I believe you would want to use the entire 6-strands of embroidery floss. You would probably want a relatively sharp embroidery/needlepoint type needle to get through the minky as well. Most of those needles are fairly dull. Minimally you'll want a large-eyed needle to not get frustrated getting the embroidery floss through the eye.