I do not have much experience quilting on my DSM (using my Singer 401). I started with a walking foot on a lap size and did fairly well, was able to manipulate it and get the needle to go where I wanted it to. However, when I got to my third one, it was bigger. By that time, I had figured out that I didn't want to drag what was somewhere between a twin and a full through my machine. So, I split the batting into three parts. I quilted the middle, added one side and quilted that, then quilted the last third.
I can't remember which book I got that out of, but it was either Divide and Conquer by Smith and milligan or Successful Machine quilting by Marti Michell. Both books show you how to break your quilt into smaller sections so it's easier to get done on a DSM.
Others have been successful on a large quilt doing the whole thing. Some say they'll never try it again.
Personally, I'd start with a smaller quilt to work out the kinks.
bkay