I've done 'big stitching' but since I'm so used to hand quilting in small stitches, my 'big stitch' comes out fairly small, lol. So...if that works for you - go for it! I have so many tops waiting to be quilted and no clue...
I've done the pearle cotton with my tiny big stitch and it looks awesome. So if that is a look you want, I would definitely say 'go for it'!