I never made many clothes but sometimes I made shorts for my boys when they were little. I appliqued cute things on them. But I really only like making quilts and the like.
I agree with you, Bear, that grain is important for quilting too.
I've noticed that some clothes made these days aren't always on the grain. I don't know if it's on purpose or not. I have some slub tees from J.Jill that aren't but they are very comfortable.