I would move like my Great Aunt did everytime she moved. Just take what you love and leave the rest. Donate it and let it go. As far as fabrics, I would probably start new. Keep two sewing machines (one for backup) and only buy what you need for a project. Of course that's easy for me to say. I still have scrapbooking supplies and I have no idea why. But if I moved, out they would go.