I almost always use flannel on the back of my quilts. Just seems to give them extra warmth.
As Patricia and Tartan said it is heavier to work with and i do use Magic Sizing (starch alternative) and use the silicon spray to make things move easier. I usually use Hobbs Fusible batting and it adheres really well to the flannel in particular , although i dont have any trouble getting it to stick to a regular cotton quilt top either.