The first layout for me is butterflies taking flight together and would be my choice.
The great thing is, whatever you do it will be great! I know that we as quilters try to stitch in all the love and hopes and prayers we can into our projects. Our recipients don't always realize the amount of time we spend thinking of them as we make them, but then they live with them longer after we are done. I would include some part of the story of "this is an original design and what it signifies to me" along with the finished quilt.