I don't roll my entire quilt in the throat either but you can also use big binder clips to hold it closed if you want. I would recommend removing them when you stop for the day because they're pretty tight.
I also quilt on a domestic and when I'm quilting the middle, I only roll a section of the quilt and then accordion fold the rest because like Tartan, I found rolling the whole thing too cumbersome to move. It's like trying to move an entire log! So I basically make a fold about 10-12in away from my machine in all directions (except inside the throat, obviously) to make a little "frame" for myself and make it easier to move the fabric in any direction.