Overall, I think I would look to him for input and guidance.
He may or may not want a quilt in his work space.
Too, he may have some great personal suggestions for you.
Better to work with him, than have the risk of disappointment for you.
There's two themes that I would consider, if it were ...
* something covid/health related ... eg. vaccine needle, the hospital's logo, etc.
* something with a nod to his personal interests beyond his hospital life
Depending on how small, your definition of small is ...
maybe consider a revolving series, not necessarily monthly, but seasonally/quarterly?