Yes! I have a Cricut Easy Press 2 and I have used it for interfacing. I have the large Easy Press 2 and I used it for putting interfacing on the backs of T-shirts for a T-shirt quilt. Worked great! Consistent coverage because of the weight and size. I was sure to use a pressing cloth on top of the interfacing. I have (embarrasingly) made the mistake of putting the interfacing glue side up too many times.
Let us know how it works for you!