Yes, it can be used in a regular machine. It's made differently than other sewing threads. Serger thread is strands that are twisted together, where other threads have a core that is wrapped. I know that if you use a very hot iron (on a cotton setting) to press serger thread, it will melt, and your seams will fall apart. So use a polyester setting when you press it. When I serge an item, instead of burying the tails, I just melt them with a candle. I have used Maxilock in my longarm, and know Kathy Barlow of Kathy Quilts mostly uses Maxilock in her longarm. I've discovered that it's stronger than I thought.
Not all serger thread is the same. Maxilock is the best. I've seen Guterman serger thread twist so badly, it forms a loop, just before it goes through the tension disks, and causes a hick-up. I've serviced sergers that had terrible thread on it, and we couldn't get a good stitch no matter what we did. Then put Maxilock on the same machine, and it worked like magic.