Knowing nothing about your particular machine, I will still jump in to this discussion. I am assuming that there have been other spools of thread that sewn without instance - if it is an issue with all threads, it might be a timing issue or an issue with a tension spring. I have an Avante and occasionally I will run across a thread spool that misbehaves. This is the list of things I do to try to correct it. If you have tried these just skip past my list lol. These are all assuming that there is no mechanical issue causing this and it has been sewing correctly on other projects. What type of thread are you using this time and how is it wound?
1, Rethread the machine, use a fresh bobbin. Make sure you have the correct size needle for the thread you have chosen, Check tension top and bottom. Check how tightly the quilt is pulled on the rollers. It should be flat but loose enough to to give a little when you push up and loose enough that you could grab it with your other hand.
2. Turn the needle to "5:30". I am assuming that your machine is using the round top industrial needle ( as opposed the the flat back domestic machine needle) Sometimes this helps - I have in seen other blogs and forums where folks even try 6:30. I recently used thread that I have used multiple times before (Glide Cleopatra Gold) and it keep breaking. I changed to a multidirectional ball point needle inserted at 5:30 and then realized that I had forgotten to change the upper tension (I was getting nesting on the back and lots of breaks).
3. After eliminating all the obvious culprits , my last thing on my list to try is either "Sewers Aid" or Silicon spray. Both do the same thing (lubricates the thread) A small drop of Sewers or a quick spritz of Silicon Spray on one side of the top spool is all you need. Before I had my Avante, I had a Voyager 17 which was very picky with what I sewed with, and this often helped.
Good luck - please let us know how you make out!!