What a lovely idea, I am no expert but if it is to be used on a bed I would keep to embroidery for your embellishments, if it is a wall hanging then you could sew on beads for your pearls and use fabric paints in the difficult parts, I have seen this done before and it is very effective. With the fabric paints you can paint on the design and heat set the paint when dry to stop the paints from bleeding out when washed.
Gal