Marsye you started a great thread that is deserving of. I too have dealt with depression and have been on meds. However, it only got worse when I found out that I have MS, multiple sclerosis. Many have mentioned here that there is a chemical imbalance of the brain and that is true. Now compound that with another illness that can sink you in more as the disease spreads whether it is MS, diabetes, high blood pressure, heart problems, etc. I have no choice at this point but to take my little "happy pill" along with my shot every day. In so doing I'm much more "controlled" with my mood swings and all. Don't get me wrong there are some down days but not as bad as before. And a note to all of you who suffer from depression or have loved ones that do: A good doctor will prescribe a blood test to check your liver levels when on medication. I have one done every year and though I've been on meds for over 7 yrs. my liver is very healthy. Just an FYI. Marsye, don't go anywhere you are more than welcomed here on this board :)