Most of the time I use the 45mm. It works well with the June Tailor Shape Cut ruler. I also have a 60mm I use sometimes when cutting, but always when trimming my quilts after they are quilted. I have the 28mm, but hardly ever use that one.

I find the 45 mm to be the most comfortable for me to handle. I rarely cut more than 2 layers of fabric and don't normally use thick things like fleece. I also had a 28 mm but found that uncomfortable as well. Don't know that I've used a 60 but it looks huge to me! I would guess the size of one's hands would be a factor as well.

it works great on fleece and flannel... and of your cutting more than a few layers at a time... I have the 28mm/ 45mm/ and 60mm.. all have their own purposes..

I have both, but use mainly the 60!

I like the 60 but seldom use it as it is for larger stacked pieces, I think

I have 3 sizes. I sold my 60mm because those blades are much bigger, the easier for you to get cut !! I don't have the physical strength I once had so I don't cut anything more that two layers at a time. I use my 45mm for most of my cutting and occasionally I use my 28mm. I even have the really small 18mm that I used when I cut hexagons for a Grandmother's flower garden. You have to always keep safety in your mine and use what you feel comfortable with. NO ONE wants to make a trip to the ER. I consider myself lucky that quilting for over 20 years, I have never cut myself with a rotary cutter.

I have 18m, 28mm, 45mm and 60mm. I mostly use the 45mm, followed by the 18mm, which I use for appliqué shapes. I sometimes use the 60mm when cutting through Insul-Bright or that tougher needle punched poly when making bags. I can't remember the last time I used the 28mm.

I use my 60mm the most but I don't often cut more than 2 layers. I use the bigger cutter because it has a bigger circumference.... therefore a longer cutting edge. I find it doesn't wear out as quickly as my 45 so I don't have to replace it as often. ... I know.... I'm a geek..... but a practical geek.

I use my 45mm Olfa most of the time~

I use my 45mm all the time. Once I needed to cut many layers and used the 45mm with a new blade with no trouble at all. I do have a 28mm and will use it soon in a DWR class I signed up for. I've never used it, but knew I would someday need that size. The 60mm seems so big. I can't think of a single time I wished I had a bigger cutter.
Sue